منابع مشابه
Teratogen update: iodine deficiency, a community teratogen.
In the last decade, iodine deficiency disorders (IDD) have become recognized as the most common preventable cause of mental retardation worldwide. Iodine deficiency interferes severely with prenatal and postnatal growth and neurologic development of individuals. It has condemned tens of millions of children to cretinism—characterized by mental and growth retardation, rigid spastic motor disorde...
متن کاملTeratogen update: fetal effects of indomethacin administration during pregnancy.
Indomethacin is a nonsteroidal anti-inflammatory analgesic used in the treatment of disorders such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Prostaglandins have a significant stimulatory effect on established labor; because indomethacin is a potent inhibitor of prostaglandin synthesis, this agent is also used in the treatment of preterm labor. Like other prostaglandin...
متن کاملTeratogen update: inorganic arsenic.
BACKGROUND Inorganic arsenic has been used by many laboratories to study the pathogenesis of exencephaly in rodents. These studies, which used predominantly injection exposures, coupled with the paucity of epidemiology data, resulted in the erroneous inference that inorganic arsenic should be considered a human teratogen. METHODS This study assembles and assesses literature analyses of older ...
متن کاملTeratogen update: methotrexate.
Methotrexate and aminopterin are folic acid antagonists that inhibit dihydrofolate reductase, resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis. Methotrexate has been used for the treatment of malignancy, rheumatic disorders, and psoriasis and termination of intrauterine pregnancy. Recently, methotrexate has become a standard treatment for ectopic pregnancy. The...
متن کاملTeratogen update: methylene blue.
Methylene blue (MB) is a cationic thiazine dye with the chemical name tetramethylthionine chloride. It has a characteristic deep blue color in the oxidized state, but the reduced form, leukomethylene blue (LMB), is colorless. Methylene blue has been widely used in a variety of clinical settings to identify anatomic (Manhes et al., ’94; Sills and Zinkham, ’94; Barber et al., ’95) and pathologic ...
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ژورنال
عنوان ژورنال: Birth Defects Research Part A: Clinical and Molecular Teratology
سال: 2005
ISSN: 1542-0752,1542-0760
DOI: 10.1002/bdra.20127